Coombs' Activity

INCORRECT

Question 1

What is the difference between Direct and Indirect Coombs' Tests?

The direct Coombs' test detects anti-human antibodies already bound to red cells, while the indirect Coomb's test detects anti-human antibodies before they bind to red cells.

Explanation.
Direct Coombs' is used to detect antibodies already bound to red cells, while in the indirect test, one adds the serum in question to known Rh+ red cells.

Immunological Techniques
University of Arizona
douglas.lake@asu.edu